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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Minerals01:26

Minerals

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Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Introduction to Electrolytes01:33

Introduction to Electrolytes

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In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
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Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Trace Elements-Role in Joint Function and Impact on Joint Diseases.

Łukasz Bryliński1, Katarzyna Brylińska2, Filip Woliński1

  • 1Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.

International Journal of Molecular Sciences
|August 14, 2025
PubMed
Summary
This summary is machine-generated.

Trace elements are crucial for joint health, influencing cell function and extracellular matrix. Imbalances in these elements, both deficiencies and excesses, contribute to joint diseases like rheumatoid arthritis and osteoarthritis.

Keywords:
anjylosing spondylitisjointsmetallomicsosteoarthritispsoriatic arthritisrheumatoid arthritisrheumatologytrace elements

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Area of Science:

  • Biochemistry
  • Orthopedics
  • Toxicology

Background:

  • Joint health significantly impacts quality of life, with diseases posing a major social challenge.
  • Risk factors include obesity, gender, and microbiome disorders, with trace elements also playing a key role.
  • Trace elements are vital for enzymes in cell function, redox metabolism, and joint component cell maturation.

Purpose of the Study:

  • To elucidate the role of trace elements in joint function and disease.
  • To describe molecular mechanisms of trace element interaction with joint cells.
  • To explore the impact of trace elements on the pathogenesis of various joint diseases.

Main Methods:

  • Review of molecular mechanisms of trace element interaction with chondrocytes, osteocytes, osteoblasts, osteoclasts, and synoviocytes.
  • Analysis of trace element roles in cell proliferation, apoptosis, and extracellular matrix synthesis.
  • Examination of trace element involvement in the pathogenesis of rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Main Results:

  • Both normal and toxic concentrations of trace elements significantly affect joint health.
  • Altered concentrations of specific elements are linked to the pathogenesis and progression of inflammatory joint diseases.
  • Trace elements influence inflammation, cell behavior, and extracellular matrix in joint disease development.

Conclusions:

  • Trace elements are critical regulators of joint health and disease.
  • Understanding their molecular roles offers insights into disease mechanisms.
  • Trace elements hold potential for therapeutic applications in treating joint diseases.