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Updated: Sep 11, 2025

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
Angiotensin II and Atherosclerosis: A New Cardiovascular Risk Factor Beyond Hypertension
Nicola Morat1, Giovanni Civieri1, Matteo Spezia2
1Cardiology Division, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
Abstract:
The pivotal role of angiotensin II (AngII) in cardiovascular disease has been firmly established, as evidenced by a robust body of literature and the broad clinical application of AngII-inhibiting therapies. AngII type 1 receptor is the primary mediator of AngII action, and its activation initiates a multitude of cellular responses that contribute to the development of hypertension, structural changes in the heart and vasculature, and damage to target organs. This review examines AngII from a different perspective, exploring the link between the renin-angiotensin-aldosterone system and cardiovascular risk beyond hypertension, with particular emphasis on atherosclerosis development and progression.
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