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Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of
Angela Falvino1, Roberto Bonanni2, Umberto Tarantino3
1Department of Biomedicine and Prevention, "Tor Vergata" University of Rome, 00133 Rome, Italy.
International Journal of Molecular Sciences
|August 14, 2025
Summary
Cellular senescence drives age-related musculoskeletal decline. Senotherapeutics and physical exercise show promise in combating these conditions, offering new strategies for healthier aging.
Area of Science:
- Gerontology
- Musculoskeletal Health
- Cellular Biology
Background:
- Aging negatively impacts musculoskeletal system function, increasing risks of osteoporosis, osteoarthritis, and sarcopenia.
- Cellular senescence, characterized by the senescence-associated secretory phenotype (SASP), drives chronic inflammation and tissue dysfunction.
- Senotherapeutics and physical exercise are emerging as key interventions for age-related musculoskeletal disorders.
Purpose of the Study:
- To review key anti-aging compounds targeting cellular senescence.
- To examine the role of physical exercise in managing age-related musculoskeletal decline.
- To explore integrated strategies for promoting healthier musculoskeletal aging.
Main Methods:
- Literature review of pharmacological senotherapeutics (natural compounds and senolytic/senomorphic drugs).
- Analysis of physical exercise as a non-pharmacological intervention for cellular senescence.
- Synthesis of findings on combined interventions for musculoskeletal health.
Main Results:
- Natural compounds (resveratrol, quercetin, etc.) and senotherapeutics (dasatinib, metformin, etc.) demonstrate potential in improving musculoskeletal health by targeting senescence.
- Physical exercise directly modulates cellular senescence and promotes tissue regeneration.
- Synergistic combinations of pharmacological and non-pharmacological approaches may optimize anti-aging strategies.
Conclusions:
- Senotherapeutics and physical exercise represent promising strategies for mitigating age-related musculoskeletal disorders.
- Further research is needed to understand mechanisms, safety, and bioavailability of senotherapeutics.
- Integrated approaches combining pharmacological and lifestyle interventions are crucial for promoting healthy musculoskeletal aging.
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