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Right Ventricular Structure and Function in Patients with Primary Aldosteronism: A Cardiac Magnetic Resonance Study
Mateusz Śpiewak1, Sylwia Kołodziejczyk-Kruk2, Agata Kubik1
1Magnetic Resonance Unit, National Institute of Cardiology, 04-628 Warsaw, Poland.
Journal of Clinical Medicine
|August 14, 2025
Summary
Primary aldosteronism (PA) patients show increased right ventricular (RV) mass and impaired RV global longitudinal strain, indicating subclinical RV dysfunction. Aldosterone levels correlate with RV dilation, and hypertension duration impacts RV function.
Area of Science:
- Cardiology
- Endocrinology
- Cardiovascular Imaging
Background:
- Aldosterone excess negatively impacts the left ventricle.
- Right ventricular (RV) function in primary aldosteronism (PA) remains understudied.
Purpose of the Study:
- To evaluate RV structure and function in PA patients using cardiac magnetic resonance imaging (CMR).
Main Methods:
- CMR assessment of RV structure and function in 30 PA patients and 30 healthy controls.
- Analysis of correlations between aldosterone levels, hypertension duration, and RV parameters.
Main Results:
- PA patients had significantly higher RV mass index (RVMi) compared to controls (p < 0.0001).
- RV end-diastolic volume index (RVEDVi) positively correlated with aldosterone levels (rho = 0.5, p = 0.005) and hypertension duration (rho = 0.4, p = 0.03).
- RV global longitudinal strain was impaired in PA patients (-16.8 ± 2.5%) versus controls (-19.6 ± 2.7%, p = 0.0001).
Conclusions:
- Primary aldosteronism patients exhibit increased RV mass and subclinical RV systolic dysfunction.
- Higher aldosterone levels are associated with RV dilation, and longer hypertension duration correlates with RV dilation and reduced RV ejection fraction.
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