Determining Reference Intervals and Median Blood Creatinine Levels in Children from Three Different Regional...

Area of Science:

• Pediatric Nephrology
• Clinical Chemistry
• Biostatistics

Background:

• Existing creatinine reference data lacks pediatric specificity.
• Accurate pediatric reference intervals are crucial for diagnosing renal conditions in children.
• This study addresses the need for age- and sex-stratified creatinine data in pediatric populations.

Purpose of the Study:

• To establish age- and sex-stratified reference intervals for serum creatinine in children.
• To develop a median (Qcr) model for pediatric serum creatinine.
• To provide a foundation for improved diagnostic accuracy in pediatric renal function assessment.

Main Methods:

• Inclusion of 9090 children (52.38% males, 47.65% females) from three regional clinical laboratories.
• Establishment of Qcr serum and reference ranges for creatinine concentration.
• Age and sex stratification of collected creatinine data.

Main Results:

• Age- and sex-stratified reference values and serum Qcr creatinine were successfully established for pediatric populations.
• Creatinine levels showed an incremental increase with age in both males and females.
• Significant regional differences in creatinine levels were observed in certain age groups (p < 0.05).

Conclusions:

• The newly established, age- and sex-stratified reference and Qcr values serve as a critical resource for clinical laboratories.
• These data empower clinicians to more accurately assess pediatric renal function.
• The findings enable more precise, individualized care for children with renal concerns.