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Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Updated: Sep 11, 2025

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Non-Surgical Rhinoplasty After Nasal Skin Cancer Reconstruction: Enhancing Esthetic Outcomes.

Shahin Tahan Shoushtari1, Charles Savoldelli2, Héloïse Gobillot3

  • 1Head and Neck Departement, Institut Universitaire de la Face et du Cou, 31 Avenue de Valombrose, UCA, 06300 Nice, France.

Journal of Clinical Medicine
|August 14, 2025
PubMed
Summary

Non-surgical rhinoplasty using hyaluronic acid significantly improved aesthetic outcomes and quality of life for patients after nasal skin cancer surgery. This minimally invasive approach offers a potential alternative to repeated reconstructive surgeries.

Keywords:
hyaluronic acidnasal reconstructionnon-surgical rhinoplastyquality of life

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Area of Science:

  • Plastic Surgery
  • Dermatology
  • Otolaryngology

Background:

  • Nasal reconstructive surgery after skin cancer resection presents significant aesthetic challenges.
  • Patient quality of life is often impacted by post-operative esthetic dissatisfaction.
  • Non-surgical rhinoplasty is explored as a less invasive alternative to traditional reconstructive methods.

Purpose of the Study:

  • To evaluate the aesthetic benefits and subjective patient outcomes of non-surgical rhinoplasty using hyaluronic acid.
  • To assess improvements in quality of life for patients following nasal skin cancer surgery.

Main Methods:

  • Retrospective study of patients with post-operative dissatisfaction after nasal skin cancer surgery.
  • Non-surgical rhinoplasty performed using hyaluronic acid injections.
  • Subjective outcomes assessed using the FACE-Q Rhinoplasty questionnaire at baseline, 1 month, and 2 months.
  • Objective volumetric changes measured using 2D and 3D Vectra H2 photography.

Main Results:

  • Six female patients (average age 58.3) with an average of five prior nasal surgeries were included.
  • Mean FACE-Q scores significantly improved from baseline (53.3) to 1 month (77.5) and 2 months (79.7) (p < 0.001).
  • Mean volumetric gain was observed: 1.13 mL at 1 month and 1.19 mL at 2 months.

Conclusions:

  • Hyaluronic acid-based non-surgical rhinoplasty shows promise in enhancing aesthetic outcomes and quality of life for patients post-nasal skin cancer surgery.
  • This minimally invasive technique may serve as a valuable option for selected cases of post-reconstructive nasal defects.
  • Further prospective studies are warranted due to the preliminary nature and small sample size of this study.