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Related Concept Videos

Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Updated: Sep 11, 2025

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Constipation in Ulcerative Colitis: An Underestimated Problem.

Gabrio Bassotti1, Sara Bologna2, Elisabetta Antonelli2

  • 1Gastroenterology, Hepatology and Digestive Endoscopy Section, Department of Medicine and Surgery, University of Perugia, 06123 Perugia, Italy.

Journal of Clinical Medicine
|August 14, 2025
PubMed
Summary
This summary is machine-generated.

Ulcerative colitis (UC) can paradoxically cause constipation due to bowel motor abnormalities and anorectal issues. Early recognition of these symptoms is crucial for accurate diagnosis and effective treatment of UC patients.

Keywords:
coloncolon motilityconstipationinflammatory bowel diseasesulcerative colitis

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • UC typically presents with diarrhea, abdominal pain, and accelerated colonic transit.
  • Some UC patients paradoxically experience constipation and fecal stasis.

Purpose of the Study:

  • To explore the underlying mechanisms of constipation in ulcerative colitis.
  • To highlight the importance of recognizing motor and anorectal abnormalities in UC patients.
  • To prevent diagnostic delays and optimize therapeutic strategies for ulcerative colitis.

Main Methods:

  • Literature review on ulcerative colitis pathophysiology.
  • Analysis of reported cases of constipation in UC patients.
  • Examination of the role of enteric nervous system damage and fibrosis.
  • Assessment of anorectal function, including pelvic floor dyssynergia.

Main Results:

  • Inflammation in UC can lead to large bowel motor dysfunction.
  • Damage to the enteric innervation and development of fibrosis contribute to altered motility.
  • Anorectal abnormalities like pelvic floor dyssynergia can cause constipation in a subset of UC patients.
  • These factors can explain the paradoxical presentation of constipation in UC.

Conclusions:

  • Constipation in UC can stem from colonic motor abnormalities and anorectal dysfunction.
  • Early identification of these issues is vital for appropriate clinical and therapeutic management.
  • Addressing these abnormalities can improve treatment response and patient outcomes in ulcerative colitis.