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Related Experiment Videos

Endogenous digoxin immunoactivity is elevated in hypertensive pregnancy.

R Valdes, S W Graves, A B Knight

    Progress in Clinical and Biological Research
    |January 1, 1985
    PubMed
    Summary

    Researchers found an endogenous digoxin-like substance in pregnant women, newborns, and amniotic fluid. Blood levels of this substance increase during pregnancy, and may be elevated in hypertensive pregnancies.

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    Area of Science:

    • Biochemistry
    • Obstetrics
    • Pharmacology

    Background:

    • An endogenous digoxin-immunoreactive substance has been detected in human blood and amniotic fluid.
    • This substance's presence and levels during pregnancy are not fully understood.

    Purpose of the Study:

    • To quantify the levels of an endogenous digoxin-immunoreactive substance in pregnant women throughout gestation.
    • To investigate potential correlations between this substance and hypertensive pregnancies.
    • To characterize the basic properties of this immunoactive substance.

    Main Methods:

    • Radioimmunoassay (RIA) to detect and quantify digoxin-like immunoreactivity.
    • Blood samples collected from pregnant women across three trimesters, newborns, and amniotic fluid.
    • Serum protein binding and heat stability assays performed on the immunoactive substance.

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    Main Results:

    • Detected endogenous digoxin-immunoreactive substance in third-trimester pregnant women, newborns, and amniotic fluid.
    • Observed a significant increase in blood levels of this substance with advancing gestational time (1st: 45 pg/ml, 2nd: 125 pg/ml, 3rd: 195 pg/ml).
    • Preliminary data indicate elevated levels in third-trimester hypertensive pregnant women (315 pg/ml).
    • The substance is water-soluble, reversibly bound to serum proteins, and its measured immunoactivity increases with heating.

    Conclusions:

    • An endogenous digoxin-like substance is present during human pregnancy, with levels increasing throughout gestation.
    • This substance may play a role in hypertensive disorders of pregnancy.
    • Further research is needed to elucidate the physiological significance of this endogenous substance.