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Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...

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Reverse Total Shoulder Arthroplasty
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Early Rotator Cuff Repair Yields Lower Retear Rates and Superior Functional Outcomes: A Systematic Review and

Alexander Baur1, Wesley Lemons1, Omar Protzuk2

  • 1Department of Research, Liberty University College of Osteopathic Medicine, 306 Liberty View Ln, Lynchburg, VA 24502, USA.

Journal of Clinical Medicine
|August 14, 2025
PubMed
Summary

Early arthroscopic rotator cuff repair (RCR) significantly reduces retear rates and enhances functional outcomes compared to delayed surgery. These findings support timely intervention for acute rotator cuff tears when clinically appropriate.

Keywords:
early operative repairfull thickness rotator cuff tearrotator cuff repairshoulder arthroscopy

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Area of Science:

  • Orthopedic Surgery
  • Sports Medicine
  • Biomedical Engineering

Background:

  • Optimal surgical timing for acute rotator cuff tears is not well-established.
  • This study investigates the impact of surgical timing on arthroscopic rotator cuff repair (RCR) outcomes.
  • Current literature lacks definitive guidelines on when to perform RCR after acute injury.

Purpose of the Study:

  • To evaluate the effect of surgical timing on retear rates after arthroscopic rotator cuff repair.
  • To assess the influence of early versus delayed RCR on functional outcomes.
  • To provide evidence-based recommendations for the timing of RCR in patients with acute rotator cuff tears.

Main Methods:

  • Systematic review and meta-analysis adhering to PRISMA guidelines.
  • Inclusion of randomized trials and cohort studies on adults with imaging-confirmed full-thickness rotator cuff tears.
  • Risk of bias assessment using ROBINS-I and meta-analysis of retear rates.

Main Results:

  • Included 13 studies with 871 patients (average age 57.9).
  • Meta-analysis of 8 studies showed early RCR significantly reduced retear rates (RR 0.60; 95% CI: 0.38-0.96).
  • Four studies indicated superior functional outcomes with early intervention.

Conclusions:

  • Early arthroscopic rotator cuff repair is associated with lower retear rates and improved functional recovery.
  • No evidence suggests early intervention is detrimental or delayed intervention is superior.
  • Findings support considering early RCR for acute rotator cuff tears when clinically indicated.