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Cyclodextrin-Based Supramolecular Hydrogels in Tissue Engineering and Regenerative Medicine
Jiamin Lin1, Yuanyuan Chen1, Xuemei Wang1
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Molecules (Basel, Switzerland)
|August 14, 2025
Summary
Cyclodextrins (CDs) form supramolecular hydrogels for tissue regeneration. These advanced materials show promise in wound healing, corneal repair, and bone regeneration, despite challenges in clinical use.
Area of Science:
- Supramolecular Chemistry
- Biomaterials Science
- Tissue Engineering
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with hydrophobic cavities and hydrophilic exteriors.
- CDs form host-guest complexes, crucial for supramolecular chemistry applications.
- Supramolecular hydrogels are advanced biomaterials with significant therapeutic potential.
Purpose of the Study:
- To review fabrication strategies for CD-based supramolecular hydrogels.
- To analyze the applications of these hydrogels in tissue engineering and regenerative medicine.
- To critically examine CD-guest interaction mechanisms and therapeutic implementations.
Main Methods:
- Literature review of CD-based supramolecular hydrogel fabrication.
- Analysis of applications in wound healing, corneal regeneration, and bone repair.
- Examination of host-guest interaction mechanisms and therapeutic strategies.
Main Results:
- CD hydrogels can be fabricated using various strategies.
- These hydrogels demonstrate significant potential in diverse tissue regeneration applications.
- Understanding CD-guest interactions is key to optimizing therapeutic outcomes.
Conclusions:
- CD-based supramolecular hydrogels offer a promising platform for tissue regeneration.
- Applications in wound healing, corneal, and bone repair are particularly noteworthy.
- Addressing clinical translation challenges is essential for future development.
