Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Food intake suppression by histidine.

J B Sheiner, P Morris, G H Anderson

    Pharmacology, Biochemistry, and Behavior
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of milk protein intake and casein-to-whey ratio in breakfast meals on postprandial glucose, satiety ratings, and subsequent meal intake.

    Journal of dairy science·2018
    Same author

    The effects of potatoes and other carbohydrate side dishes consumed with meat on food intake, glycemia and satiety response in children.

    Nutrition & diabetes·2016
    Same author

    A comparison of effects of lard and hydrogenated vegetable shortening on the development of high-fat diet-induced obesity in rats.

    Nutrition & diabetes·2015
    Same author

    Multivitamin supplementation during pregnancy alters body weight and macronutrient selection in Wistar rat offspring.

    Journal of developmental origins of health and disease·2014
    Same author

    The effect of high multivitamin diet during pregnancy on food intake and glucose metabolism in Wistar rat offspring fed low-vitamin diets post weaning.

    Journal of developmental origins of health and disease·2014
    Same author

    The role of alginates in regulation of food intake and glycemia: a gastroenterological perspective.

    Critical reviews in food science and nutrition·2014

    Histidine supplementation suppresses food intake in rats, particularly under nocturnal feeding conditions. This effect is dose-dependent and linked to increased brain histamine levels, without altering macronutrient selection.

    Area of Science:

    • Neuroscience
    • Nutritional Science
    • Physiology

    Background:

    • Histidine is an essential amino acid involved in various physiological processes.
    • Understanding the role of amino acids in appetite regulation is crucial for metabolic health.

    Purpose of the Study:

    • To investigate the effects of histidine on food intake and macronutrient selection in rats.
    • To explore the relationship between histidine administration, feeding patterns, and brain neurotransmitter levels.

    Main Methods:

    • Rats were administered varying doses of histidine (0-500 mg/kg) via intraperitoneal injection.
    • Feeding behavior was monitored under different feeding schedules (12-hour diurnal, 12-hour nocturnal, 4-hour).
    • Brain histidine and histamine levels were measured following histidine injections.

    Related Experiment Videos

    Main Results:

    • Histidine suppressed total food intake in rats adapted to a 12-hour feeding period, but not a 4-hour period.
    • Nocturnal feeders showed a greater suppression (50%) compared to diurnal feeders (20%).
    • Food intake suppression correlated with histidine dose (p<0.05), with 375 mg/kg being the effective threshold. Histidine administration elevated brain histidine and histamine levels.
    • No effect on protein or carbohydrate intake was observed.

    Conclusions:

    • Histidine influences total food intake, potentially via alterations in brain histidine and histamine.
    • Histidine does not appear to affect macronutrient selection.
    • Feeding patterns significantly modulate the appetite-suppressing effects of histidine.