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Three-Dimensional Disassemblable Scaffolds for Breast Reconstruction
Viktoriia Kiseleva1,2, Aida Bagdasarian1,2, Polina Vishnyakova1,2
1National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Moscow 117997, Russia.
Polymers
|August 14, 2025
Summary
Three-dimensional (3D) disassemblable scaffolds offer advanced solutions for breast reconstruction, utilizing biomaterials and bioprinting for patient-specific tissue regeneration. These scaffolds enhance outcomes in reconstructive plastic surgery.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Plastic Surgery
Background:
- Breast reconstruction surgery aims to restore mammary gland form and function, offering significant medical and psychological benefits.
- Autologous tissue reconstruction provides natural appearance and sensation, minimizing implant risks.
- Three-dimensional (3D) disassemblable scaffolds represent an advancement over traditional methods, enabling patient-specific adaptation and tissue support.
Purpose of the Study:
- To review the current state of 3D disassemblable scaffolds for mammary gland reconstruction.
- To analyze the advantages and disadvantages of these scaffolds.
- To discuss future research and clinical applications.
Main Methods:
- Integration of autologous cells and tissues with synthetic (PLA, PGA, PLGA, PCL) or natural (alginate, chitosan, collagen, etc.) scaffolds.
- Development of hybrid biomaterials combining synthetic and natural polymers.
- Advancement of 3D bioprinting for patient-specific scaffold fabrication with cellular therapies (e.g., mesenchymal stromal cells, growth factors).
Main Results:
- 3D disassemblable scaffolds offer patient-specific anatomical adaptation and structural support for tissue regeneration.
- Hybrid biomaterials and 3D bioprinting are key research directions.
- Scaffolds can incorporate cellular therapies to promote tissue healing and vascularization.
Conclusions:
- 3D disassemblable scaffolds show significant promise for post-mastectomy breast reconstruction.
- Further research into novel biomaterials and bioprinting technologies is crucial for clinical translation.
- These advanced scaffolds have the potential to improve reconstructive surgery outcomes.
