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Accelerated Hydrolytic Degradation of PLA/Magnesium Composite Films: Material Properties and Stem Cell Interaction
Valentina Fabi1, Maria Luisa Valicenti2, Franco Dominici3
1Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, Largo dell'Università snc, 01100 Viterbo, Italy.
Abstract:
The accelerated hydrolytic degradation of poly(L-lactide) (PLA)/magnesium (Mg) composite films was investigated to elucidate the influence of surface modification of Mg particles on the degradation behavior and characteristics of PLA composites. Accelerated degradation studies were conducted at 60 °C in a pH 7.4 phosphate-buffered solution over 7 weeks, with degradation monitored using several techniques: mass loss, water absorption, thermal analysis, and Raman spectroscopy. The results indicated that all composite films experienced more than 90% mass loss at the end of experiment; however, PLA/5MgTT and PLA/5MgPEI exhibited the highest resistance to degradation, likely due to the protective effect of the surface modification induced by thermal treatment and polyethylenimine (PEI). Notably, these characteristics did not compromise the biocompatibility or osteogenic potential of the films, which remained comparable to the control samples when tested on human bone marrow multipotent mesenchymal/stromal cells.
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