Preparation of glycine-pectin complex and its application in drug delivery system

The side chain modification of apple pectin was carried out to enhance its usablitity as a drug carrier. During the sequential drug release, indomethacin released with very low rate in the early two hours in artificial gastric juice, and then it released with much higher rate in the next six hours in artificial intestinal juice. Among all the tested samples, glycine-pectin complex showed the highest difference between the amount of cumulative drug release in artificial gastric juice and artificial intestinal juice. Consequently, the glycine-pectin complex had low DE and high hydrophilicity. The indomethacin loaded on the modified pectin was able to release slowly in artificial gastric juice and release rapidly in artificial intestinal juice, which meets the demands of colon-localized drug delivery system.