Frailty, Mosaic Loss of Y Chromosome, and Mortality in Older Chinese Males
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View abstract on PubMed
Summary
This summary is machine-generated.Mosaic loss of the Y chromosome (mLOY) may mediate the link between frailty and mortality risk in older men. This study highlights mLOY
Area Of Science
- Gerontology
- Genetics
- Epidemiology
Background
- Mosaic loss of the Y chromosome (mLOY) and frailty are age-related phenomena.
- The interplay between mLOY, frailty, and mortality risk is not well understood, particularly the potential mediating role of mLOY.
Purpose Of The Study
- To investigate the relationship between frailty and mLOY in older men.
- To examine the mediating effect of mLOY on the association between frailty and mortality risk.
Main Methods
- Prospective cohort study of 8947 middle-aged and older men.
- Frailty assessed using a 34-deficit Frailty Index (FI).
- mLOY estimated from genotyping data; mortality tracked until 2018; Cox regression and mediation analysis used.
Main Results
- Frail men showed significantly higher mLOY levels compared to robust men.
- Both frailty and mLOY were associated with increased mortality risk.
- mLOY mediated 27.3%, 53.9%, and 23.5% of the frailty-mortality association for all-cause, cancer, and other causes of death, respectively.
- These associations were significant in men aged 65 years and older.
Conclusions
- Frailty is associated with increased mLOY in older men.
- mLOY plays a mediating role in the relationship between frailty and mortality risk in men aged 65 and older.
- mLOY is an important factor in male aging and mortality.
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