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Surprises From the Basal Ganglia: Stop and Go Have New Meaning

Ann M Graybiel1

  • 1McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|August 14, 2025
PubMed
Summary

New research suggests a revised basal ganglia model with parallel direct and indirect pathways. These striosome-based circuits may offer novel therapeutic strategies for movement disorders like Parkinson's disease.

Keywords:
Parkinson's diseasecanonical direct and indirect basal ganglia pathwaysmood and movement controlpallidumstriatumstriosome

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