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Association between body roundness index and advanced cardiovascular-kidney-metabolic syndrome

Yuehui Chen1, Hongxiang Tu1, Min Liang1

  • 1Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Frontiers in Nutrition
|August 14, 2025
PubMed

Insights

Higher body roundness index (BRI) is linked to increased risk of cardiovascular-kidney-metabolic (CKM) syndrome. BRI may be a better predictor of CKM syndrome than traditional measures.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Health
  • Anthropometry

Background:

  • Cardiovascular-kidney-metabolic (CKM) syndrome involves interconnected cardiovascular, renal, and metabolic issues.
  • Body roundness index (BRI) is a novel anthropometric measure estimating body fat percentage.
  • The study investigates the relationship between BRI and advanced CKM syndrome.

Purpose of the Study:

  • To determine the association between BRI and the risk of advanced CKM syndrome.
  • To evaluate BRI's predictive capability for CKM syndrome.
  • To compare BRI with other anthropometric measures for CKM risk stratification.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (2005-2018).
  • Categorized participants into BRI tertiles for analysis.
  • Employed regression and receiver operating characteristic analyses to assess BRI's association and predictive value for CKM syndrome.

Main Results:

  • A cohort of 12,329 participants was analyzed, with a 12.20% prevalence of advanced CKM syndrome.
  • Higher BRI tertiles showed a significantly increased prevalence of advanced CKM syndrome.
  • BRI proved to be a stronger predictor of advanced CKM syndrome compared to other anthropometric indices.

Conclusions:

  • Elevated BRI correlates with a higher incidence of advanced CKM syndrome.
  • BRI shows greater predictive power for CKM syndrome than traditional measures.
  • BRI merits consideration as a preferred metric for assessing CKM syndrome risk.
Abstract

Keywords:
CKMNHANESRCSbody roundness indexobesity

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