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Feasibility And Utility Of The Days Of Antibiotic Spectrum Coverage (dasc) In National Antimicrobial Use Surveillance In Japan.

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Feasibility And Utility Of The Days Of Antibiotic Spectrum Coverage (dasc) In National Antimicrobial Use Surveillance In Japan.

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Feasibility and utility of the days of antibiotic spectrum coverage (DASC) in national antimicrobial use surveillance

Ichiro Kawamura¹, Sanae Suzuki², Mio Endo²

¹Department of Infectious Diseases, Osaka International Cancer Institute, Osaka, Japan.

Antimicrobial Stewardship & Healthcare Epidemiology : ASHE

|August 14, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Integrating Days of Antibiotic Spectrum Coverage (DASC) into national surveillance is feasible. This novel metric, alongside DASC/DOT, offers a more comprehensive view of antibiotic use than traditional Days of Therapy (DOT) alone.

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Area of Science:

Healthcare epidemiology
Antimicrobial stewardship
Public health surveillance

Background:

Traditional metrics like Days of Therapy (DOT) do not account for antibiotic spectrum breadth.
A novel metric, Days of Antibiotic Spectrum Coverage (DASC), was developed to address this limitation.
The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system collects antibiotic consumption data.

Purpose of the Study:

To evaluate the feasibility of integrating the DASC metric into the J-SIPHE surveillance system.
To assess how DASC provides a more nuanced understanding of antibiotic utilization compared to DOT.
To explore the implications of DASC for antimicrobial stewardship initiatives.

Main Methods:

A retrospective observational study was conducted using data from 1,833 hospitals participating in J-SIPHE between 2019 and 2022.

Antibiotic use was measured using DOT, DASC, and the DASC/DOT ratio.

Antibiotic spectrum scores were derived from published data or expert consensus.

Main Results:

Median DOT and DASC per 1,000 patient-days decreased from 2019 to 2022, while DASC/DOT remained stable.
Proportional use of antibiotic classes varied by hospital size, with differences observed between DOT and DASC measures.
Broad-spectrum antibiotics like carbapenems and fluoroquinolones were ranked higher by DASC than DOT.

Conclusions:

The integration of DASC metrics into national surveillance systems like J-SIPHE is feasible.
DASC and DASC/DOT offer a more comprehensive assessment of antimicrobial use by incorporating spectrum breadth.
These metrics can enhance antimicrobial stewardship by providing better benchmarking and informing intervention strategies.