Association between single and multiple dietary vitamin exposure and heart failure risk: a cross-sectional study

Heart failure (HF) is a prevalent cardiovascular disease exhibiting a complex interplay with dietary vitamin intake. This study employed a comprehensive methodology to investigate the association between exposure to single and multiple dietary vitamins and the risk of HF, with the ultimate goal of providing an evidence-based framework for HF prevention and management strategies.

Data on subjects over the age of 18 years were extracted from the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES). Three different covariate-adjusted models were constructed to analyze the single effects of dietary vitamins A, C, D, K, B6, B12, B1 and B2 intake on HF. The dose-response relationship between each vitamin and HF risk was analyzed via a restricted cubic spline (RCS).

This study enrolled 13,025 subjects and categorized them into the non-HF (N=12,623) and the HF (N=402) groups. The HF group exhibited a lower intake of vitamins A, K, B6, B1 and B2 compared with the non-HF group (P<0.05). The fully adjusted model demonstrated a negative association of the intake of vitamins A [odds ratio (OR): 0.750, 95% confidence interval (CI): 0.565, 0.997], K (OR: 0.702, 95% CI: 0.523, 0.942), D (OR: 0.715, 95% CI: 0.535, 0.955), B12 (OR: 0.703, 95% CI: 0.533, 0.927), B1 (OR: 0.680, 95% CI: 0.489, 0.946), and B2 (OR: 0.673, 95% CI: 0.490, 0.925) with HF. An obvious association of high levels of vitamins A, K, B1 and B2 with a reduced probability of HF was found across the three models (all P<0.05). The RCS analysis revealed a linear correlation between vitamins K, B6, B1, B2 and HF (P for nonlinear >0.05, P for overall <0.05).

HF risk was found to decrease with increasing intake of dietary vitamins A, K, B1 and B2. There was a negative correlation of vitamins K, B6, B1, B2 intake with HF.