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METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value

Xinyu Zhang1, Yuan Chen1, Min Li2,3

  • 1School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.

Oncology Reviews
|August 14, 2025
PubMed

Insights

Methyltransferase-like 1 (METTL1) is a key enzyme in RNA methylation, increasingly studied for its role in cancer. This review explores METTL1's functions in tumor development and potential as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Methyltransferase-like 1 (METTL1) is an enzyme involved in RNA methylation.
  • Its role in cancer has gained significant attention in recent years.
  • Understanding METTL1's functions is crucial for cancer research.

Purpose of the Study:

  • To review the diverse roles of METTL1 in various cancers.
  • To elucidate the mechanisms of METTL1 in tumorigenesis, progression, and metastasis.
  • To discuss therapeutic strategies targeting METTL1.

Main Methods:

  • Literature review of recent research findings on METTL1 in cancer.
  • Analysis of studies focusing on METTL1's molecular mechanisms.
  • Synthesis of information on therapeutic potential and targeting strategies.

Main Results:

  • METTL1 plays multifaceted roles in the development and spread of different cancers.
  • Specific molecular pathways influenced by METTL1 in tumorigenesis are identified.
  • Evidence supports METTL1's potential as a target for novel cancer therapies.

Conclusions:

  • METTL1 is a significant factor in cancer biology.
  • Targeting METTL1 offers a promising avenue for cancer treatment development.
  • Further research into METTL1-targeted therapies is warranted.
Keywords:
METTL1RNA methylationcancertherapeutic targettumor mechanism

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