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Related Experiment Video

Updated: May 11, 2026

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

Published on: April 9, 2017

Illuminating HBV with multi-scale modeling.

Shawn A Means¹, Md A Ali², Harvey Ho¹

¹Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.

Frontiers in Systems Biology

|August 14, 2025

Summary

This summary is machine-generated.

Chronic hepatitis-B viral (HBV) infection affects millions globally. This study explores how the liver

Keywords:

HBV liver mathematical model HBV hepatatis-B virus multiscale sinusoid spatial zonation

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Last Updated: May 11, 2026

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper

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Published on: April 9, 2017

Multimodal Hierarchical Imaging of Serial Sections for Finding Specific Cellular Targets within Large Volumes

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Published on: March 20, 2018

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

Hepatology
Immunology
Mathematical Biology

Background:

Chronic hepatitis-B viral (HBV) infection impacts an estimated 250 million people worldwide.
The liver's unique microenvironment, or 'liver terrain,' features gradients of oxygen and nutrients within sinusoids, influencing immune responses.
Specialized liver cells, Kupffer cells (KC) and liver sinusoidal endothelial cells (LSECs), play critical roles in pathogen detection and immune modulation at blood entry points.

Purpose of the Study:

To investigate the intricate relationship between the liver terrain's spatial and structural features and the dynamics of HBV infection.
To understand how HBV exploits specific liver microenvironmental conditions for invasion and persistence.
To identify potential therapeutic strategies by illuminating HBV's reliance on the liver terrain.

Main Methods:

Utilized mathematical modeling to simulate and analyze spatial and structural variations within the liver terrain.
Integrated multi-scale modeling approaches to dissect complex interactions between HBV and liver microenvironment components.
Coordinated modeling insights with experimental observations to validate findings.

Main Results:

HBV targets key metabolic proteins, particularly at periportal sites where KC and LSECs are concentrated.
Failure of KC and LSEC spatial configurations may inadvertently facilitate HBV invasion and entrenchment.
Mathematical modeling revealed subtle, competing dynamics governing HBV infection within the liver terrain.

Conclusions:

The liver terrain's specific structural and spatial configurations are critical factors in HBV infection dynamics.
Understanding these microenvironmental dependencies offers potential avenues for developing novel strategies to combat HBV.
Multi-scale modeling is a promising approach to unraveling HBV's complex interactions within the liver.