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An unusual kappa immunoglobulin antigen present on the membrane of T and B lymphocytes
Several K immunoglobulin antisera out of a large number studied showed the unique property of reacting with a membrane structure present on all T and B lymphocytes examined. This antigen was detected on lymphocytes by indirect fluorescence, direct fluorescence, and by cytotoxic analysis. Absorption of the antiserum by all K myeloma proteins, K Bence-Jones proteins, and kappa light chains removed the activity; L proteins had no effect. The possibility that the cross-reacting membrane antigen is part of the HL-A system was discussed.
Several K immunoglobulin antisera out of a large number studied showed the unique property of reacting with a membrane structure present on all T and B lymphocytes examined. This antigen was detected on lymphocytes by indirect fluorescence, direct fluorescence, and by cytotoxic analysis. Absorption of the antiserum by all K myeloma proteins, K Bence-Jones proteins, and kappa light chains removed the activity; L proteins had no effect. The possibility that the cross-reacting membrane antigen is part of the HL-A system was discussed.