Related Experiment Video
Updated: Sep 11, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Cancer Clusters: Geographic Disparities in Head and Neck Cancer Incidence in Greater Manchester and East Cheshire
Nikhil Chotai1,2, Mahesh Yadav3, Danuksha K Amarasena4
1Oncology, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Abstract:
Objective This study aimed to assess whether a statistically significant correlation exists between socioeconomic status, measured by the Index of Multiple Deprivation (IMD), and the incidence of head and neck cancer (HNC) in Greater Manchester and East Cheshire. Understanding this relationship can help inform targeted public health interventions and reduce healthcare disparities. Methods Using Multidisciplinary Team (MDT) lists, 236 HNC patients from Manchester University NHS Foundation Trust were identified. Patient demographics and residential postcodes were extracted from the HIVE electronic patient record system. Postcodes were then mapped to IMD deciles using the UK Government's official postcode-to-IMD lookup tool. This allowed for the categorisation of patients by area-level socioeconomic deprivation. Results The analysis revealed a negative correlation (ρ = -0.21) between socioeconomic status, as indicated by IMD decile, and the incidence of HNC cases. Statistical analysis showed that this correlation was not statistically significant at the α = 0.05 level. Conclusion While this study did not identify a statistically significant correlation between socioeconomic deprivation and HNC incidence, a weak negative trend was observed. These exploratory findings suggest potential geographic and socioeconomic patterns that warrant further investigation. Understanding these trends may support more targeted public health strategies - especially in regions with a higher disease burden - and contribute to efforts aimed at earlier diagnosis and improved health outcomes.
Related Concept Videos
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
Veins of Head and Neck
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...

