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Updated: Sep 11, 2025

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Histopathological Analysis of Myocardial Remodeling Following Heart Failure: A Cadaveric Case Report

Anthony DeSomma1, Jeung Woon Lee2

  • 1Anatomy, Lake Erie College of Osteopathic Medicine, Bradenton, USA.

Cureus
|August 14, 2025
PubMed

Insights

Heart failure causes myocardial remodeling, leading to fibrosis and cardiomyocyte hypertrophy. Histopathology confirmed these structural changes, indicating a stiffer heart and impaired function.

Area of Science:

  • Cardiovascular pathology
  • Cardiac histology

Background:

  • Cardiovascular disease and aging contribute to myocardial remodeling, impacting cardiac function.
  • Understanding structural changes like fibrosis and hypertrophy is crucial for heart failure pathophysiology.

Observation:

  • This study analyzed myocardial tissue from a heart failure cadaver and two controls.
  • Histopathological examination used Masson's Trichrome and Cresyl Violet staining.

Findings:

  • Increased collagen deposition and fibrosis were observed in the heart failure sample.
  • Cardiomyocyte hypertrophy was evident, consistent with cellular remodeling in heart failure.

Implications:

  • These findings provide histological evidence of myocardial remodeling in heart failure.
  • Further quantitative analysis is needed to understand the functional implications of these pathological changes.

Keywords:
cardiac remodelingcresyl violetheart failurehistopathologymasson’s trichromemyocardial fibrosispost-mortem

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