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Updated: Sep 11, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Intraoperative cryo nerve block during lower extremity amputation prevents the development of phantom limb pain
Lizabeth A O'Connor1, Curtis C Quinn1, Bryan Houseman2
1Department of Surgery, Division of Cardiovascular and Thoracic Surgery, Elliot Health System, Manchester, NH.
Abstract:
Phantom limb pain is the experience of painful sensations in an amputated limb. It is highly prevalent with unclear etiology. There is no consensus regarding the ideal prevention and treatment of this condition. We report a case of a 58-year-old female who underwent a right below-knee amputation with concomitant application of cryo nerve block to the tibial, deep, and superficial peroneal nerves. The patient denied phantom limb pain at 1 year following surgery. This case highlights the potential benefits of cryo nerve block for postoperative pain reduction and prevention of phantom limb pain.
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