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The role of m5C, m1A and m7G modifications in tumors of urinary system

Wei Xue1, Yuanyuan Zhao1, Gong Zhang1

  • 1Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in Cell and Developmental Biology
|August 14, 2025
PubMed

Insights

Investigating RNA modifications like N6-methyladenosine (m1A), 5-methylcytosine (m5C), and N7-methylguanosine (m7G) in urological tumors offers new therapeutic targets. Understanding these epigenetic changes is key to improving treatments for kidney, bladder, and prostate cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Urological tumors, including kidney, bladder, and prostate cancers, present significant therapeutic challenges due to recurrence and metastasis.
  • RNA modifications are increasingly recognized as critical regulators of gene expression impacting cancer biology.
  • The precise roles of specific RNA modifications in urological malignancies require further elucidation.

Purpose of the Study:

  • To review and synthesize current knowledge on the regulatory roles of key RNA modifications in urological tumors.
  • To explore the molecular mechanisms and pathways through which RNA modifications influence tumorigenesis, progression, metastasis, and drug resistance.
  • To identify potential therapeutic targets based on RNA modification dynamics in urological cancers.

Main Methods:

  • Literature review of recent research on RNA modifications in urological cancers.
  • Analysis of studies focusing on N6-methyladenosine (m1A), 5-methylcytosine (m5C), and N7-methylguanosine (m7G).
  • Examination of the impact of these modifications on gene expression and cellular processes in urological tumor models.

Main Results:

  • RNA modifications like m1A, m5C, and m7G are implicated in critical aspects of urological tumor development and progression.
  • These modifications influence tumorigenesis, metastasis, and resistance to cancer therapies.
  • Specific pathways and molecular players involved in RNA modification-driven oncogenesis are being uncovered.

Conclusions:

  • RNA modifications represent a promising area for novel therapeutic strategies in urological oncology.
  • Further research into the functional significance of m1A, m5C, and m7G can lead to improved treatment outcomes.
  • Targeting RNA modification pathways may overcome limitations of current therapies for urological malignancies.
Keywords:
RNA modificationm1Am5Cm7Gurological tumours

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