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Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
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History of COVID-19 as a Risk Factor for Cardiac Arrhythmias: A Case-Control Study

Miriam Elizabeth Miranda-Corrales1, Joselyn Elizabeth Begazo-Paredes2, Barbara Alejandra Garcia-Tejada3

  • 1Escuela de Postgrado, Vicerrectorado de Investigacion, Universidad Catolica de Santa Maria, Arequipa, Peru.

Cardiology Research
|August 14, 2025
PubMed

Insights

A prior COVID-19 infection significantly increases the risk of developing cardiac arrhythmias. This study emphasizes the need for cardiac monitoring in individuals with a history of SARS-CoV-2 infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, resulted in significant global morbidity and mortality.
  • Persistent sequelae of COVID-19 require ongoing evaluation, particularly cardiovascular complications.

Purpose of the Study:

  • To investigate the association between a history of COVID-19 infection and the incidence of cardiac arrhythmias.
  • To assess cardiac arrhythmia risk in outpatients with prior SARS-CoV-2 infection.

Main Methods:

  • A retrospective, analytical, unmatched case-control study was conducted.
  • 252 adult patients undergoing 24-h Holter monitoring were analyzed.
  • Logistic regression was used to determine the odds of arrhythmias in patients with and without a COVID-19 history, adjusting for age and sex.

Main Results:

  • A history of COVID-19 was more prevalent in patients with cardiac arrhythmias (70.6%) compared to controls (50.5%).
  • Prior COVID-19 infection was associated with more than double the odds of presenting arrhythmias (OR: 2.35).
  • This association remained significant after adjusting for age and sex (OR: 2.12).

Conclusions:

  • A history of COVID-19 is significantly linked to an increased likelihood of cardiac arrhythmias.
  • These findings underscore the importance of cardiac evaluations for patients with a history of SARS-CoV-2 infection.
Abstract

Keywords:
COVID-19Cardiac arrhythmiaHolterSequelae

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