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Updated: Sep 11, 2025

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Remimazolam for Procedural Sedation During Cardioversion.

Mitchell Hughes1, Cameron Kramer1, Marco Corridore2

  • 1Heritage College of Osteopathic Medicine - Dublin Campus, Dublin, Ohio and Ohio University, Athens, OH, USA.

Cardiology Research
|August 14, 2025
PubMed
Summary

Remimazolam, a novel benzodiazepine, effectively sedated adult patients for cardioversion. This rapid-acting sedative provided amnesia without significant respiratory or hemodynamic adverse effects, indicating its potential for procedural sedation.

Keywords:
BenzodiazepineCardioversionProcedural sedationRemimazolam

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Remimazolam is a short-acting benzodiazepine with sedative, anxiolytic, and amnestic properties.
  • It is rapidly metabolized by tissue esterases, leading to quick recovery of clinical effects.
  • Previous studies show efficacy in general anesthesia and procedural sedation.

Purpose of the Study:

  • To evaluate the efficacy and safety of remimazolam for sedation during cardioversion in adult patients.

Main Methods:

  • Retrospective review of six adult patients undergoing cardioversion.
  • Intravenous remimazolam as the primary sedative agent.
  • Analysis of administered doses, adjunctive agents, and adverse events.

Main Results:

  • Remimazolam was used as the primary sedative in all six patients.
  • No significant respiratory or hemodynamic adverse effects were observed.
  • All patients achieved adequate amnesia, with no recall of the procedure.

Conclusions:

  • Remimazolam appears to be an effective and safe sedative for cardioversion in adult patients.
  • A single 5 mg bolus dose provided adequate sedation and amnesia.
  • It demonstrated minimal impact on hemodynamic and respiratory function.