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Sinus node dysfunction in a young patient with Hodgkin lymphoma: a case report.
Gabriela-Elena Marascu1,2, Madalina Schmidt3, Ruxandra Vidlescu1,3
1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Eroii Sanitari Boulevard, No 8, District 5, Bucharest 050474, Romania.
European Heart Journal. Case Reports
|August 14, 2025
Summary
This case report details a young male with Hodgkin lymphoma (HL) who presented with asymptomatic sinus node dysfunction, an early indicator of cardiac involvement. This finding highlights the importance of cardiac monitoring in lymphoma patients.
Area of Science:
- Cardiology
- Oncology
- Electrophysiology
Background:
- Sinus node dysfunction is a rare bradyarrhythmia in lymphoma patients.
- It has not been previously reported in individuals with Hodgkin lymphoma (HL).
Observation:
- A 17-year-old male with stage IV A nodular sclerosis classic type HL presented with asymptomatic sinus node dysfunction.
- Electrocardiogram revealed intermittent sinus arrest with a junctional rhythm.
- Imaging studies showed mediastinal adenopathies infiltrating the cardiac structures, including the right atrium and interatrial septum.
Findings:
- The patient's cardiac conduction and rhythm abnormalities improved with chemotherapy.
- This suggests a direct link between the lymphoma and cardiac involvement.
Implications:
- This is the first reported case of Hodgkin lymphoma presenting with sinus node dysfunction as an early sign of cardiac involvement.
- It underscores the need for vigilance regarding cardiac complications in HL patients.
- Early detection and management of cardiac issues may improve patient outcomes.
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