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The iron woman: a case report of contemporary cardiac support

Jeremy A Brooksbank1, Nikolaos Spilias2, Carmela D Tan3

  • 1TriStar Centennial Medical Center, Advanced Heart Failure and Transplant Cardiology, 2400 Patterson St. Suite 502, Nashville, TN 37203, USA.

European Heart Journal. Case Reports
|August 14, 2025
PubMed

Insights

This case study details a patient with heart failure with reduced ejection fraction and severe mitral regurgitation who underwent multiple device therapies. It highlights the progression of advanced heart failure treatments, including mechanical support and cardiac transplantation.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Heart Failure Management

Background:

  • Modern cardiovascular practice employs diverse devices and procedures for functional and structural heart disease.
  • Heart failure with reduced ejection fraction (HFrEF) and mitral regurgitation are common clinical challenges.

Observation:

  • A female patient with HFrEF and severe mitral regurgitation received a comprehensive suite of device-based therapies.
  • Therapies included mitral transcatheter edge-to-edge repair, percutaneous mitral annuloplasty (Carillon device), temporary mechanical circulatory support, and a durable left ventricular assist device.

Findings:

  • The patient ultimately required cardiac transplantation following the failure of other interventions.
  • This case illustrates a stepwise progression through advanced heart failure management strategies.

Implications:

  • Understanding the indications and data for various device therapies is crucial for managing complex heart failure.
  • This case underscores the potential need for escalating mechanical circulatory support and transplantation in refractory cases.
Abstract

Keywords:
CardiomyopathyCarillonCase reportLVADMitraClipSecondary mitral regurgitationTransplantation

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