Preparation of ″Five-in-One″ Chitosan Hydrogel for Infectious Wound Repair
Linxin Yang1,2, Xin Zhang1,2, Wei He3
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
ACS Applied Materials & Interfaces
|August 14, 2025
Summary
This study developed a novel five-in-one hydrogel wound dressing from chitosan and tannic acid. The advanced CS/TA dressing effectively treats infected wounds by adhering to tissue, self-healing, and providing antibacterial and antioxidant properties.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Bacterial infections and oxidative stress impair wound healing, necessitating advanced treatments beyond traditional gauze and systemic antibiotics.
- Existing treatments face challenges like secondary injury, insufficient drug delivery, and systemic toxicity.
- Hydrogel dressings offer breathability, biocompatibility, and modifiability, making them promising for wound care.
Purpose of the Study:
- To design and characterize a novel "five-in-one" hydrogel wound dressing with enhanced properties for infected wound treatment.
- To evaluate the efficacy of the developed hydrogel in promoting wound healing by addressing key challenges like adhesion, inflammation, and infection.
Main Methods:
- A novel hydrogel dressing (CS/TA) was synthesized using natural components: chitosan and tannic acid.
- The CS/TA hydrogel was characterized for tissue adhesion, self-healing, extensibility, antibacterial, and antioxidant capabilities.
- The hydrogel's performance was evaluated in an infected wound model.
Main Results:
- The CS/TA hydrogel demonstrated excellent tissue adhesion, self-healing ability, and extensibility, conforming to dynamic wound environments.
- The dressing effectively eliminated bacteria and scavenged free radicals, significantly reducing inflammation.
- Accelerated wound healing was observed in the infected wound model using the CS/TA hydrogel dressing.
Conclusions:
- The developed CS/TA hydrogel dressing integrates five crucial capabilities for effective infected wound management.
- This novel hydrogel design offers a promising alternative to conventional wound dressings, enhancing healing outcomes.
- The study highlights the potential of multifunctional hydrogels in advancing infected wound treatment strategies.
