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Related Experiment Video

Updated: Sep 11, 2025

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
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Tissue Engineering for Oral Mucosa Biofabrication: A Systematic Review and Meta-Analysis.

Miguel A Martin-Piedra1,2, Manuel Albendin-Moreno1, Adriana Olivares-Abril1

  • 1Tissue Engineering Group, Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain.

Tissue Engineering. Part B, Reviews
|August 14, 2025
PubMed
Summary

Tissue-engineered oral mucosa shows clinical potential for oral lesion reconstruction. Biofabrication advancements using keratinocytes and fibroblasts yield promising results for artificial oral mucosa development.

Keywords:
advanced therapiesmeta-analysisoral mucosasystematic reviewtissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Oral mucosa reconstruction is crucial for treating oral lesions.
  • Tissue engineering offers a promising alternative to traditional methods.
  • Artificial oral mucosa development is advancing rapidly.

Purpose of the Study:

  • To systematically review and meta-analyze advancements in artificial oral mucosa biofabrication.
  • To evaluate components, methods, and outcomes of tissue-engineered oral mucosa.
  • To assess the clinical potential of current biofabrication techniques.

Main Methods:

  • Systematic review and meta-analysis of 57 studies.
  • Focus on preclinical in vitro research.
  • Analysis of cell sources, biomaterials, and biofabrication techniques.

Main Results:

  • Predominant cell sources: oral keratinocytes and fibroblasts; biomaterial: collagen.
  • Immersion and air technique was the primary biofabrication method.
  • Average epithelial thickness: 73.18 μm; maturation score: 5.13/6. In vivo studies showed better stratification.

Conclusions:

  • Tissue-engineered oral mucosa demonstrates significant potential for clinical applications.
  • Further research may optimize epithelial thickness and stratification.
  • Biofabrication strategies are key to successful oral mucosa regeneration.