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Updated: May 11, 2026
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Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
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Estimating the Opportunity for Early Detection of Ovarian Cancer Using Individual-Patient Data from a Large
Marc D Ryser1,2, Shannon T Holloway1, Raphaël Morsomme3
1Department of Population Health Sciences, Duke University Medical Center, Durham, North Carolina.
Summary
Ovarian cancer screening effectiveness varies by cancer type and method. Multimodal screening (MMS) and ultrasound screening (USS) show different detection windows for high-grade serous cancers versus other types.
Area of Science:
- Oncology
- Screening Technologies
- Biostatistics
Background:
- The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) evaluated multimodal screening (MMS) and transvaginal ultrasound screening (USS) for ovarian cancer (OC).
- The trial did not find a reduction in OC mortality with either screening method compared to no screening.
- UKCTOCS data offer a valuable resource for understanding OC interception opportunities.
Purpose of the Study:
- To estimate ovarian cancer natural history using Bayesian inference.
- To quantify the preclinical detectable phase (PCDP) for different OC subtypes and screening modalities.
Main Methods:
- Utilized Bayesian inference on individual screening and cancer diagnosis records from the UKCTOCS trial.
- Analyzed data from 199,499 women, including 674,806 screens and 2,025 OC diagnoses.
- Compared PCDP for high-grade serous cancers (HGSCs) and non-HGSCs across MMS and USS arms.
Main Results:
- The estimated PCDP for HGSCs was 1.7 years, significantly shorter than 7.8 years for non-HGSCs.
- PCDP for HGSCs was longer with MMS (2.2 years) than USS (0.8 years).
- PCDP for non-HGSCs was shorter with MMS (2.7 years) than USS (8.2 years).
Conclusions:
- The window for intercepting ovarian cancer is highly dependent on histological subtype and the screening modality used.
- Enhancing early detection benefits requires extending the interception window by combining different screening tests.
