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Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos
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Bacteriophage therapy in clinical practice: case studies of Pseudomonas aeruginosa infections

Ahmed Elfadadny1,2, Rokaia F Ragab1,3, Osama Aldesoky Abd Alaziz4

  • 1Laboratory of Internal Medicine, Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan.

Journal of Chemotherapy (Florence, Italy)
|August 14, 2025
PubMed

Insights

Multidrug-resistant Pseudomonas aeruginosa infections are a growing problem. Bacteriophage therapy offers a targeted alternative, showing promise in combination with antibiotics for better eradication and reduced resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Bacteriophage Therapy

Background:

  • Rising incidence of multidrug-resistant (MDR) Pseudomonas aeruginosa infections presents significant clinical challenges.
  • Treatment failure with antibiotics and limitations in surgical intervention necessitate alternative therapeutic strategies.

Purpose of the Study:

  • To review the current status of bacteriophage therapy (BT) for P. aeruginosa infections.
  • To explore the mechanisms of action, clinical applications, and future prospects of BT.

Main Methods:

  • Review of recent advancements in phage isolation, purification, and genomic characterization.
  • Analysis of studies on phage-antibiotic synergy and clinical compassionate use cases.

Main Results:

  • Bacteriophage therapy is a promising alternative for MDR P. aeruginosa infections.
  • Phage-antibiotic synergy may enhance bacterial eradication and mitigate resistance development.

Conclusions:

  • BT offers a targeted approach to combat persistent P. aeruginosa infections.
  • Challenges include optimizing dosing, understanding host immune responses, and navigating regulatory pathways.
Keywords:
Bacteriophage therapyP. aeruginosacasesclinical application

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