Anthracycline Dose, Myocardial Injury, and Change in Left Ventricular Function in the Cardiac CARE Trial
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View abstract on PubMed
Summary
This summary is machine-generated.High-sensitivity cardiac troponin I (hs-cTnI) levels did not predict left ventricular ejection fraction decline after anthracycline chemotherapy. Mild myocardial injury indicated by hs-cTnI may not reliably predict subsequent cardiac dysfunction in cancer survivors.
Area Of Science
- Cardiology
- Oncology
- Cardio-oncology
Background
- Anthracycline chemotherapy can cause long-term cardiovascular damage in cancer survivors.
- Cardiac troponin is used for risk stratification, but its association with cardiac dysfunction after anthracyclines, especially with high-sensitivity assays, is unclear.
Purpose Of The Study
- To investigate the relationship between high-sensitivity cardiac troponin I (hs-cTnI), anthracycline dose, and left ventricular (LV) function changes.
- To assess if hs-cTnI can predict cardiac dysfunction following anthracycline treatment.
Main Methods
- Prospective study of patients undergoing anthracycline chemotherapy with elevated baseline hs-cTnI.
- Hs-cTnI measured serially; LV function assessed by cardiac magnetic resonance at baseline and 6 months post-chemotherapy.
Main Results
- Hs-cTnI correlated with treatment cycles but not cumulative anthracycline dose.
- A minority of patients (14.0%) experienced a >10% decline in LV ejection fraction (LVEF).
- Hs-cTnI showed a weak correlation with LVEF change and predicted global longitudinal strain.
Conclusions
- Hs-cTnI levels were not significantly associated with cumulative anthracycline dose or substantial LVEF decline.
- Mild myocardial injury, indicated by hs-cTnI, may not be a reliable predictor of subsequent cardiac dysfunction after anthracycline chemotherapy.
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