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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Association of Volume Status Assessed by Bioimpedance with BP in CKD
Katherine Scovner Ravi1,2, Enass Elsayed1,2, Brendon L Neuen3
1Brigham and Women's Hospital, Boston, Massachusetts.
Kidney360
|August 14, 2025
Insights
In chronic kidney disease (CKD) patients, shorter vector length (indicating more body fluid) and decreasing vector length were linked to higher systolic blood pressure (BP). Volume status may impact hypertension management in CKD.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biomedical Engineering
Background:
- Hypertension is prevalent in chronic kidney disease (CKD) patients, increasing cardiovascular risk.
- Hypervolemia contributes to hypertension, but its link with volume biomarkers in CKD is not well understood.
Purpose of the Study:
- To investigate the association between body fluid volume, assessed by vector length, and blood pressure in CKD patients.
- To determine if changes in volume over time correlate with blood pressure changes.
Main Methods:
- Utilized data from 5,384 CKD patients in the Chronic Renal Insufficiency Cohort (CRIC) study.
- Employed linear regression models to analyze the relationship between vector length (bioimpedance proxy for volume) and systolic/diastolic blood pressure (BP).
- Assessed non-linear associations and changes in vector length and BP over two years.
Main Results:
- A non-linear association was observed between vector length and systolic BP.
- The lowest quartile of vector length (hypervolemia) was linked to 3.2 mmHg higher systolic BP compared to the third quartile.
- A decrease in vector length over two years was associated with a 3.0 mmHg increase in systolic BP; diastolic BP showed no association.
Conclusions:
- Shorter and decreasing vector length are independently associated with higher and increasing systolic BP in CKD patients.
- Further research is needed to explore if optimizing volume status using bioimpedance can improve BP control in CKD.
Abstract
No abstract available in PubMed .
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