Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parallel Processing01:20

Parallel Processing

227
The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
227
Multimachine Stability01:25

Multimachine Stability

229
Multimachine stability analysis is crucial for understanding the dynamics and stability of power systems with multiple synchronous machines. The objective is to solve the swing equations for a network of M machines connected to an N-bus power system.
In analyzing the system, the nodal equations represent the relationship between bus voltages, machine voltages, and machine currents. The nodal equation is given by:
229
RACE - Rapid Amplification of cDNA Ends02:35

RACE - Rapid Amplification of cDNA Ends

6.5K
Rapid Amplification of cDNA Ends, or RACE, is one of the most effective methods to obtain a full-length cDNA from an mRNA sequence between a known internal region to the unknown sequence at the 5’ or 3’ end. The unknown region is cloned in the cDNA by a gene-specific primer that binds the known end, and a hybrid primer that attaches a predefined anchor sequence to the unknown end of the cDNA. The sequence in between is amplified by PCR with an anchor primer and a gene-specific...
6.5K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.4K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.4K
Sanger Sequencing01:57

Sanger Sequencing

757.1K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
757.1K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

529
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
529

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accelign: a GPU-based library for accelerating pairwise sequence alignment.

BMC bioinformatics·2026
Same author

Local administration of polymyxin B-conjugated Akkermansia muciniphila outer membrane vesicles attenuate asthma by suppressing M2 macrophage polarization.

Science China. Life sciences·2026
Same author

From Nature's Design to Heritage Preservation: Biomimetic Hydroxyapatite for Consolidating Waterlogged Archaeological Ivories.

ACS applied materials & interfaces·2026
Same author

Agar and Chitosan Hydrogel Electrolytes with Solvation Sheath Enabling High Ionic Conductivity for High-Performance Zinc-Iodine Batteries.

ChemSusChem·2026
Same author

Stable organic radical luminescent groups and their applications in nano-diagnosis and therapy.

Chemical communications (Cambridge, England)·2026
Same author

gpuPairHMM: High-Speed Pair-HMM Forward Algorithm for DNA Variant Calling on GPUs.

IEEE transactions on computational biology and bioinformatics·2026
Same journal

A Multi-Modal Framework for Phage-Host Interaction Prediction Using Multi-View Contrastive Learning.

IEEE transactions on computational biology and bioinformatics·2026
Same journal

Decoding Gene-Disease Associations with Computational Methods: A Survey.

IEEE transactions on computational biology and bioinformatics·2026
Same journal

A Competitive Coevolution-based Cancer Driver Pathway Identification Algorithm for Maximizing Coverage, Mutual Exclusivity, and Subnet Importance.

IEEE transactions on computational biology and bioinformatics·2026
Same journal

Prediction of GO Terms Based on Partitioning PPI Networks into Highly Connected Components.

IEEE transactions on computational biology and bioinformatics·2026
Same journal

Modeling and Tracking of Heterogeneous Cell Populations via Open Multi-Agent Systems.

IEEE transactions on computational biology and bioinformatics·2026
Same journal

Parameter Efficient Deep Learning Models for Multi-Target Binding Affinity and hERG Cardiotoxicity Prediction.

IEEE transactions on computational biology and bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Sep 11, 2025

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
04:58

Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

Published on: December 13, 2024

2.9K

RabbitBAM: Accelerating BAM File Manipulation on Multi-Core Platforms.

Lifeng Yan, Zhan Zhao, Zekun Yin

    IEEE Transactions on Computational Biology and Bioinformatics
    |August 14, 2025
    PubMed
    Summary
    This summary is machine-generated.

    RabbitBAM is a new library that speeds up the processing of biological data files (BAM format) by efficiently using multi-core processors. It significantly accelerates next-generation and third-generation sequencing data analysis.

    More Related Videos

    Detection of Copy Number Alterations Using Single Cell Sequencing
    09:45

    Detection of Copy Number Alterations Using Single Cell Sequencing

    Published on: February 17, 2017

    11.7K
    ATAC-seq Assay with Low Mitochondrial DNA Contamination from Primary Human CD4+ T Lymphocytes
    08:36

    ATAC-seq Assay with Low Mitochondrial DNA Contamination from Primary Human CD4+ T Lymphocytes

    Published on: March 22, 2019

    12.8K

    Related Experiment Videos

    Last Updated: Sep 11, 2025

    Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
    04:58

    Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance

    Published on: December 13, 2024

    2.9K
    Detection of Copy Number Alterations Using Single Cell Sequencing
    09:45

    Detection of Copy Number Alterations Using Single Cell Sequencing

    Published on: February 17, 2017

    11.7K
    ATAC-seq Assay with Low Mitochondrial DNA Contamination from Primary Human CD4+ T Lymphocytes
    08:36

    ATAC-seq Assay with Low Mitochondrial DNA Contamination from Primary Human CD4+ T Lymphocytes

    Published on: March 22, 2019

    12.8K

    Area of Science:

    • Bioinformatics
    • Computational Biology
    • Genomics

    Background:

    • The rapid increase in biological data necessitates efficient file I/O.
    • The Binary Alignment Map (BAM) format is standard for storing aligned sequencing data.
    • Existing BAM I/O libraries underutilize multi-core processors, leading to performance bottlenecks.

    Purpose of the Study:

    • To develop a high-performance BAM file I/O library that leverages modern multi-core architectures.
    • To overcome the limitations of current libraries in handling large-scale sequencing data.

    Main Methods:

    • Introduction of RabbitBAM, a novel BAM file I/O library.
    • Implementation of pre-parsing and parallel parsing techniques to enhance efficiency.
    • Optimization of multi-threaded data handling using lock-free queues and memory pools.

    Main Results:

    • RabbitBAM achieves significant speedups: 2.1-3.3x on next-generation sequencing data and 1-2.2x on third-generation sequencing data compared to SAMtools (HTSlib).
    • Case studies in BAM file quality control and sorting demonstrate 1.4-2.4x speedups using RabbitBAM.
    • Demonstrated improvements in CPU utilization and parallel efficiency.

    Conclusions:

    • RabbitBAM offers a substantial performance improvement for BAM file processing.
    • The library effectively addresses the I/O bottlenecks in analyzing large-scale sequencing data.
    • RabbitBAM provides a valuable tool for accelerating genomic data analysis workflows.