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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Receiver Operating Characteristic Plot01:15

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A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: Sep 11, 2025

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
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TSH Cutoffs and Recurrence Risk in Differentiated Thyroid Carcinomas: A Systematic Review and Meta-Analysis.

Yoon Young Cho1, Soo Hyun Ahn2, Mijin Kim3

  • 1Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea.

The Journal of Clinical Endocrinology and Metabolism
|August 14, 2025
PubMed
Summary

Thyroid stimulating hormone (TSH) suppression did not significantly impact differentiated thyroid cancer recurrence overall. However, TSH suppression may reduce recurrence risk in high-risk patients with distant metastases.

Keywords:
TSHrecurrencesuppressionthyroid cancer

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Area of Science:

  • Endocrinology
  • Oncology
  • Clinical Research

Background:

  • Differentiated thyroid cancer (DTC) management often involves TSH suppression.
  • The optimal TSH level to minimize recurrence risk remains debated.
  • American Thyroid Association (ATA) stratifies DTC recurrence risk.

Purpose of the Study:

  • To evaluate the association between TSH levels and DTC recurrence risk.
  • To analyze recurrence rates based on variable TSH cut-offs (0.1, 0.5, 2.0 mIU/L).
  • To investigate TSH's role stratified by ATA risk categories.

Main Methods:

  • Systematic search of Ovid-Medline, EMBASE, and Cochrane databases (up to March 2024).
  • Inclusion of randomized controlled trials and observational studies.
  • Meta-analysis and subgroup analysis based on TSH cut-offs and ATA risk stratification.

Main Results:

  • Analysis of 5,320 patients with an overall recurrence rate of 18%.
  • No significant difference in pooled recurrence risk across TSH cut-offs (0.1, 0.5, 2.0 mIU/L).
  • Increased recurrence risk observed at TSH ≥0.1 mIU/L and TSH ≥2.0 mIU/L in sensitivity analysis; higher risk in patients with distant metastases (HR 3.3) at TSH ≥0.1 mIU/L.

Conclusions:

  • TSH suppression degree did not influence overall DTC recurrence.
  • TSH suppression may be beneficial for high-risk DTC patients with distant metastases.
  • Further research may clarify TSH's role in specific patient subgroups.