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Updated: Sep 11, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evaluating chatbots in psychiatry: Rasch-based insights into clinical knowledge and reasoning
Yu Chang1,2, Si-Sheng Huang3,4, Wen-Yu Hsu2,3,4
1Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.
Leading chatbots show potential for psychiatric clinical support, with ChatGPT-o1-preview excelling in knowledge and reasoning. However, limitations highlight the need for human oversight in AI integration for patient safety.
Area of Science:
- Psychiatry
- Artificial Intelligence
- Medical Informatics
Background:
- Chatbots are emerging as tools for clinical support in psychiatry.
- Evaluating the capabilities of these AI tools is crucial for safe integration.
Purpose of the Study:
- To systematically assess the clinical knowledge and reasoning abilities of 27 leading chatbots in psychiatry.
- To identify strengths and limitations of current AI in psychiatric decision support.
Main Methods:
- Utilized 160 multiple-choice questions from Taiwan Psychiatry Licensing Examinations.
- Employed Rasch analysis for quantitative performance evaluation.
- Conducted qualitative assessment of chatbot reasoning processes.
Main Results:
- OpenAI's ChatGPT-o1-preview achieved a Rasch ability score of 2.23, surpassing the passing threshold (p < 0.001).
- ChatGPT demonstrated strong diagnostic and therapeutic reasoning but had limitations in factual recall and niche topics.
- Identified reasoning biases in some chatbot responses.
Conclusions:
- Advanced chatbots show significant potential as clinical decision-support tools in psychiatry.
- Current AI limitations necessitate rigorous human oversight for patient safety.
- Continuous evaluation and domain-specific training are essential for safe AI implementation in clinical practice.
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