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Factors Associated With Symptom Burden Among Pediatric Patients With Cancer.
Adam P Yan1,2, L Lee Dupuis1,3, Catherine Aftandilian4
1Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
JCO Oncology Practice
|August 14, 2025
Summary
Routine symptom screening using the Symptom Screening in Pediatrics Tool (SSPedi) reduced symptom burden in pediatric cancer patients. Males and sites with more physicians reported lower symptom burden.
Area of Science:
- Pediatric Oncology
- Clinical Trials
- Symptom Management
Background:
- Pediatric cancer patients experience significant symptom burden.
- Effective symptom management is crucial for improving quality of life.
- The Symptom Screening in Pediatrics Tool (SSPedi) measures symptom burden.
Purpose of the Study:
- To identify factors associated with self-reported symptom burden in pediatric cancer patients.
- To evaluate the impact of routine symptom screening on symptom burden.
Main Methods:
- Secondary analysis of a cluster randomized trial involving 430 pediatric cancer patients.
- Intervention: thrice-weekly SSPedi screening and symptom management pathways.
- Outcome: total SSPedi scores at baseline, week 4, and week 8.
Main Results:
- Symptom burden (SSPedi scores) significantly decreased over time and in the intervention group.
- Males and sites with higher physician staffing ratios reported lower symptom burden.
- Females experienced higher symptom burden.
Conclusions:
- Routine symptom screening and care pathways reduce symptom burden in pediatric cancer patients.
- Physician staffing ratios are associated with lower symptom burden.
- Findings can inform implementation of symptom screening programs.
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