Risk of Self-Harm Among Individuals Diagnosed With Endometriosis
Peter Thiel1, Olga Bougie, Jessica Pudwell
1Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Saskatchewan, the Department of Obstetrics and Gynecology, University of Toronto, and ICES, Toronto, the Department of Obstetrics and Gynecology, Queen's University, Kingston Health Sciences Center, Kingston, and the Department of Obstetrics and Gynecology, Trillium Health Partners, Institute for Better Health, Mississauga, Ontario, and the Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
None:
Endometriosis is a chronic inflammatory condition that has been linked to mental health outcomes. We conducted a population-based, retrospective, matched cohort study using administrative health data (2010-2022) from Ontario, Canada, to assess the risk of self-harm, overdose, and suicide in patients with endometriosis, accounting for prior psychiatric utilization. The cohort included 56,053 patients with endometriosis and 112,106 individuals in a matched control group. The primary outcome was a composite of intentional self-harm, overdose, and suicide. Endometriosis was associated with a higher risk of the composite outcome (adjusted hazard ratio 1.42, 95% CI, 1.27-1.59), particularly among individuals with no or minimal prior psychiatric care. These findings highlight the importance of considering mental health needs for patients newly diagnosed with endometriosis.
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