Solitary splenic metastasis secondary to endometrial adenocarcinoma: A case report

Endometrial adenocarcinoma is the most common gynecological malignancy and it usually metastasizes to different places. However, a solitary metastatic lesion to the spleen from endometrial carcinoma is a rare occurrence. Herein, we report a case of Solitary splenic metastasis secondary to endometrial adenocarcinoma.

A 64-year-old female presented to the emergency room complaining of severe constipation, abdominal pain, nausea, fever, fatigue, general weakness, and weight loss. Clinical exam showed signs of bowel obstruction and abdominal guarding. US followed by a CT scan showed a large pelvic mass and a hypo-intense lesion in the lower pole of the spleen and both were removed surgically. Pathological examination confirmed the diagnosis of a solitary splenic metastasis secondary to endometrial adenocarcinoma.

This case is the 20th case of its kind reported in the medical literature of a solitary splenic metastatic lesion originating from endometrial adenocarcinoma. Additionally, almost all of the cases published in the medical literature, to our knowledge, were cases of symptomatic endometrial adenocarcinoma which was treated accordingly until remission was achieved, then the disease relapsed as a metastatic lesion in the spleen which makes our case unique as the patient first presented with splenomegaly-related symptoms.

The successful diagnosis and management of this rare presentation underscore the significance of a collaborative and multidisciplinary approach in the treatment of these patients.