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Adrenic acid suppresses liver regeneration by inhibiting Serpina1c expression

Ying Chen1, Yue-Jie Xu2, Rong Zhang2

  • 1Jinzhou Medical University Graduate Training Base (Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine), Jinzhou, 121001, Liaoning, China.

Biochemical and Biophysical Research Communications
|August 14, 2025
PubMed

Insights

Adrenic acid (ADA) impairs liver regeneration by suppressing Serpina1c. Restoring Serpina1c function rescues this defect, offering a potential therapeutic strategy for chronic liver diseases.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Diminished hepatocyte regeneration is a hallmark of chronic liver diseases.
  • Elevated adrenic acid (ADA) is linked to chronic liver conditions, but its role in liver regeneration is unclear.

Purpose of the Study:

  • To investigate the direct effect of ADA on hepatocyte proliferation and liver regeneration.
  • To elucidate the molecular mechanisms underlying ADA's impact on liver repair.

Main Methods:

  • Utilized a murine partial hepatectomy (PHx) model to assess liver regeneration.
  • Employed transcriptomic analysis to identify ADA's downstream targets.
  • Conducted in vitro experiments using AML12 hepatocytes to study ADA's effects and rescue strategies.

Main Results:

  • Systemic ADA administration significantly impaired liver regeneration in mice, indicated by reduced liver-to-body weight ratios and decreased Ki67-positive hepatocytes.
  • Transcriptomic analysis revealed Serpina1c as a key downstream target suppressed by ADA.
  • ADA inhibited AML12 hepatocyte proliferation in vitro, an effect reversed by Serpina1c overexpression.

Conclusions:

  • ADA-mediated suppression of Serpina1c inhibits hepatic regeneration.
  • Restoring Serpina1c function can rescue ADA-induced defects in liver regeneration.
  • Targeting the ADA-Serpina1c pathway presents a precise therapeutic approach for liver regeneration disorders.
Keywords:
Adrenic acidChronic liver diseasesLiver regenerationSerpina1c

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