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Forensic pathology and infant deaths: A recent update
Fotios Chatzinikolaou1, Eleftherios Vavoulidis2, Dimitrios Koutsoukis1
1Department of Forensic Medicine and Toxicology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Legal Medicine (Tokyo, Japan)
|August 14, 2025
Summary
Investigating infant deaths is challenging due to unclear causes. New forensic tools like molecular autopsy and imaging improve accuracy in determining natural, accidental, or intentional infant deaths.
Area of Science:
- Forensic Pathology
- Pediatric Death Investigation
Background:
- Infant death investigations face challenges in distinguishing natural, accidental, and intentional causes.
- Traditional autopsy methods often lack definitive markers for asphyxia or trauma, leading to diagnostic ambiguity in cases of sudden unexpected infant death (SUID), neonaticide, and infanticide.
- Inconsistent classification protocols and overlapping post-mortem findings complicate accurate determinations.
Purpose of the Study:
- To review evolving methodologies in forensic infant death investigations.
- To highlight the impact of emerging forensic tools on investigative practices.
- To emphasize the need for collaboration and standardization in the field.
Main Methods:
- This review synthesizes current evidence on advanced forensic techniques.
- It examines the application of post-mortem imaging, molecular autopsy, biomechanical modeling, and toxicological screening.
- The study analyzes how these methods address limitations in traditional autopsy.
Main Results:
- Recent advancements are transforming infant death investigations.
- New tools offer improved potential for identifying causes of death, including subtle trauma or asphyxia.
- Integration of these technologies can reduce diagnostic ambiguity.
Conclusions:
- There is a critical need for evidence-based integration of emerging forensic tools.
- Collaboration among forensic experts and standardization of protocols are essential.
- Adopting advanced methodologies will enhance the accuracy and reliability of infant death investigations.

