Related Experiment Video
Updated: Sep 11, 2025

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
Published on: June 29, 2022
Paced electrical alternans with syncope: Time for emergent pericardiocentesis?
Michael C Downey1, John S Zakaib2
1Minneapolis Heart Institute at Abbott Northwestern Hospital, 800 East 28th Street, Minneapolis, MN 55407, United States of America; Minneapolis Heart Institute Foundation, 920 East 28th Suite #100, Minneapolis, MN 55407, United States of America; Cardiology Division, Department of Internal Medicine, Hennepin Healthcare, 701 Park Avenue, Minneapolis, MN 55413, United States of America.
Left bundle branch area pacing (LBBAP) can paradoxically capture the LBB even with LBB block. Pacing faster than the LBB refractory period causes alternating capture and non-selective pacing, impacting lead placement assessment.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Device Technology
Background:
- Left bundle branch area pacing (LBBAP) is a common strategy for cardiac device therapies.
- Established criteria exist for LBBAP capture, even in cases of left bundle branch block (LBB).
Purpose of the Study:
- To investigate the implications of LBBAP rate relative to the intrinsic refractory period of the left bundle branch (LBB).
- To highlight a specific case demonstrating the physiological consequences of pacing exceeding LBB refractoriness.
Main Methods:
- Case study analysis of a patient undergoing LBBAP.
- Observation of pacing capture patterns in relation to the LBB refractory period.
Main Results:
- A case of LBBAP at a rate exceeding the LBB refractory period was observed.
- This resulted in alternating LBBAP capture and non-selective septal pacing.
Conclusions:
- Understanding the LBB refractory period is crucial for LBBAP.
- This physiological insight is important for accurate lead placement assessment during LBBAP implantation.
Related Concept Videos
Dysrhythmias V: Evaluating Dysrhythmias
Pulse rhythm
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Cardiopulmonary Resuscitation IV: Pharmacological Management
Cardiopulmonary Resuscitation III: AED Use

