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Updated: Sep 11, 2025
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
Published on: January 3, 2025
Multifunctional roles of MicroRNAs in regulating cell death during cerebral ischemic injury
Qiuyue Yang1, Hongfa Cheng1, Qiuxia Zhang1
1Capital Medical University, Beijing, China.
Abstract:
Ischemic stroke is characterized by cerebral ischemic injury, in which multiple forms of cell death-including apoptosis, pyroptosis, autophagy-dependent cell death, and ferroptosis- contribute significantly to severe pathological outcomes. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, play a pivotal role in modulating cell death mechanisms induced by cerebral ischemic injury. Using 'cerebral ischemia' and 'microRNA' as keywords, we conducted a literature search on the PubMed database. This review systematically summarizes research from the past five years on the multifunctional roles, clinical significance, and therapeutic applications of miRNAs in cell death associated with cerebral ischemic injury. Moreover, this review briefly discusses alterations in miRNA expression in clinical settings and their implications, as well as summarizes pharmacological interventions that mitigate cerebral ischemic injury through miRNA regulation.
Insights
MicroRNAs (miRNAs) are crucial in regulating cell death after cerebral ischemic injury. This review covers their roles, clinical significance, and therapeutic potential in stroke treatment.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Ischemic stroke causes severe brain damage through various cell death pathways like apoptosis and ferroptosis.
- MicroRNAs (miRNAs) are key regulators of gene expression influencing these cell death mechanisms.
Purpose of the Study:
- To systematically review the roles, clinical significance, and therapeutic applications of miRNAs in cerebral ischemic injury-induced cell death.
- To summarize recent advancements in miRNA research related to ischemic stroke.
Main Methods:
- Literature search on PubMed using keywords 'cerebral ischemia' and 'microRNA'.
- Systematic review of research published in the last five years.
Main Results:
- miRNAs play multifaceted roles in modulating apoptosis, pyroptosis, autophagy-dependent cell death, and ferroptosis in cerebral ischemia.
- Alterations in miRNA expression are observed in clinical settings, impacting stroke outcomes.
- Pharmacological interventions targeting miRNA regulation show promise in mitigating ischemic injury.
Conclusions:
- miRNAs are significant regulators of cell death pathways in ischemic stroke.
- Understanding miRNA functions offers potential for novel therapeutic strategies.
- Further research into miRNA-based treatments is warranted for cerebral ischemic injury.
