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Updated: Sep 11, 2025

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
An alkaline phosphatase-activatable photosensitizer based on 2-anthrol for selective targeting of cancer cells
Yusha Li1, Yuki Masuda1, Yuzuha Miyazawa1
1Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Abstract:
2-Anthrol (2) was found to induce protein degradation under neutral conditions and without the need for additives upon visible light irradiation. Based on this simple and small scaffold, a novel photosensitizer 4 was designed and synthesized, which is specifically activated by the tumor-associated biomarker alkaline phosphatase (ALP). Upon visible light exposure, 4 exhibited selective photo-cytotoxicity toward cancer cells overexpressing ALP, demonstrating its potential as a targeted phototherapeutic agent.

