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Association of TP53 and EZH2 with salivary adenoid cystic carcinoma

  • 0Department of Stomatology, The First Hospital of Hebei Medical University. Shijiazhuang, Hebei, 050030, PR China.
Journal of Stomatology, Oral and Maxillofacial Surgery +

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August 14, 2025

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August 14, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

TP53 and EZH2 are highly expressed in salivary adenoid cystic carcinoma, suggesting they may be key molecular targets for this rare cancer. Further research into these genes could lead to new therapeutic strategies for salivary gland tumors.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genomics

Background

  • Adenoid cystic carcinoma (ACC) is a rare salivary gland malignancy originating from duct cells, known for local invasion.
  • The specific roles of TP53 and EZH2 in salivary ACC remain largely undefined.

Purpose Of The Study

  • To investigate the molecular mechanisms and potential therapeutic targets in salivary adenoid cystic carcinoma.
  • To clarify the relationship between TP53, EZH2, and salivary ACC.

Main Methods

  • Analysis of gene expression datasets (GSE153002, GSE153283) to identify differentially expressed genes (DEGs).
  • Utilized Weighted Gene Co-expression Network Analysis (WGCNA), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network analysis.
  • Validated core gene expression using RT-qPCR and Western Blot (WB) assays.

Main Results

  • Identified 98 intersection DEGs, with enrichment in inflammatory response, cell cycle, and cancer-related pathways (MAPK, P53, PI3K-Akt).
  • Identified TP53 and EZH2 as core genes, showing high expression in salivary ACC tissues via heatmap analysis.
  • Comparative Toxicogenomics Database (CTD) analysis confirmed the association of TP53 and EZH2 with salivary gland neoplasms and adenoid cystic carcinoma.

Conclusions

  • TP53 and EZH2 are significantly upregulated in salivary adenoid cystic carcinoma.
  • These highly expressed genes represent potential molecular targets for therapeutic intervention in salivary ACC.

Keywords:

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