Pharmacokinetics of theobromine in male rats in different traumatic conditions

The pharmacokinetics of theobromine after four i.v. administrations was investigated in male rats submitted to an increasingly "stressing" experimental design. Calculated parameters agreed with those previously described. No difference was found between baseline and pathological conditions, or between dosing and sampling at different sites. The findings raise consistent objections about the general utility of widely applied small mammal trauma models.