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Related Experiment Video

Updated: Sep 11, 2025

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Published on: November 2, 2014

Multicondition and multimodal temporal profile inference during mouse embryonic development.

Ran Zhang^1,2, Chengxiang Qiu¹, Galina Filippova³

¹Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

Genome Research

|August 14, 2025

Summary

This summary is machine-generated.

Sunbear integrates diverse single-cell data across time, enabling imputation and alignment of cellular profiles. This framework reveals developmental insights and predicts gene expression dynamics, even with missing data.

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Last Updated: Sep 11, 2025

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Long-term Time Lapse Imaging of Mouse Cochlear Explants

Published on: November 2, 2014

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

Area of Science:

Computational Biology
Genomics
Developmental Biology

Background:

Single-cell measurements offer insights into cellular dynamics but face challenges due to disruptive sampling and mismatched time points.
Integrating multimodal (e.g., scRNA-seq, scATAC-seq) and multicondition (e.g., sex, batch) single-cell data across time is complex.

Purpose of the Study:

To introduce Sunbear, a joint modeling framework for integrating multicondition and multimodal single-cell profiles over time.
To enable imputation of temporal profile changes, alignment of profiles across datasets and modalities, and extrapolation of missing data.

Main Methods:

Development of a novel joint modeling framework named Sunbear.
Application of Sunbear to analyze mouse embryonic development datasets.
Utilizing Sunbear for imputation, alignment, and extrapolation tasks.

Main Results:

Sunbear successfully integrated multicondition and multimodal single-cell data across time.
The framework revealed sex-biased transcription patterns during mouse embryonic development.
Dynamic relationships between epigenetic priming and transcription were predicted for cells lacking multimodal profiles.

Conclusions:

Sunbear provides a powerful approach for analyzing complex single-cell time-series data.
The framework facilitates the projection of single-cell snapshots into comprehensive multimodal and multicondition views of cellular trajectories.
Sunbear enhances our understanding of developmental processes and gene regulation by overcoming data integration challenges.